Geometric control of myogenic cell fate
نویسندگان
چکیده
منابع مشابه
Geometric control of myogenic cell fate
This work combines expertise in stem cell biology and bioengineering to define the system for geometric control of proliferation and differentiation of myogenic progenitor cells. We have created an artificial niche of myogenic progenitor cells, namely, modified extracellular matrix (ECM) substrates with spatially embedded growth or differentiation factors (GF, DF) that predictably direct muscle...
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Cell differentiation is mediated by lineage-determining transcription factors. We show that chromodomain helicase DNA-binding domain 2 (Chd2), a SNF2 chromatin remodelling enzyme family member, interacts with MyoD and myogenic gene regulatory sequences to specifically mark these loci via deposition of the histone variant H3.3 prior to cell differentiation. Directed and genome-wide analysis of e...
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Tissue engineering requires tight control of stem cell function. Among many physical signals such as stretch and perfusion, geometrical cues have received much attention and have widely been recognized as an important factor in scaffold design. Here we review a variety of approaches that control stem cell fate at different levels of strictness, including micro-contact printing, microwells, dire...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2006
ISSN: 1176-9114
DOI: 10.2147/nano.2006.1.2.203